We report an exact numerical study on disorder effect in double-Weyl semimetals, and compare exact numerical solutions for the quasiparticle behavior with the Born approximation and renormalization group results. It is revealed that the low-energy quasiparticle properties are renormalized by multiple-impurity scattering processes,leading to apparent power-law behavior of the self-energy. Therefore, the quasiparticle residue surrounding nodal points is considerably reduced and vanishes as ZE ∝Er with nonuniversal exponent . We show that such unusual behavior of the quasiparticle leads to strong temperature dependence of diffusive conductivity. Remarkably, we also find a universal minimum conductivity along the direction of linear dispersion at the nodal point, which can be directly observed by experimentalist.