Serum Lipoprotein (a) Concentration in Patients with Nephrotic Syndrome and Its Clinical Implication

被引：0

作者：

杨晓

王惠玲

朱中华

邓安国

机构：

来源：

华中科技大学学报(医学英德文版) | 1998年 / 04期

关键词：

lipoprotein(a); nephrotic syndrome; dislipedemia;

D O I：

暂无

中图分类号：

R692.3 [肾炎];

学科分类号：

1002 ; 100210 ;

摘要：

<正>Serum lipoprotein(a) [Lp(a)] concentration was determined in 42 patients with primary nephrotic syndrome (NS) and the relationships between Lp (a) and plasma lipids, apolipoproteins, serum creatinine (Scr), albumin, urinary proteins (Upro) were also analyzed. The results showed that: (1) serum Lp(a) concentrations in the patients with NS were higher than those in healthy controls;(2) the levels of serum Lp (a) were correlated positively with total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), apolipoprotein B (Apo-B), Upros (Upro). It is concluded that the NS patients had the potential risk of suffering from coronary artery disease, glomerular sclerosis and thrombosis. The remission of NS may partially decrease the serum Lp(a) levels. Further studies are needed to explore the prevention and treatment of dislipedemia in patients with NS.

引用

页码：236 / 238

页数：3

共 9 条

[1]

Webb A T,Plant M,Reareley D A et al.Lipid and Lp(a) concentrations in renal transplant patients. Nephrology Dialysis Transplantation . 1992

[2]

Brown M S,Goldstein J L.Teaching old dogmas new tricks. Nature . 1987

[3]

Galle J,Heinloth A,Schwedler S et al.Effect of HDL and atherogenity lipoprotein on formation of O2 and rennin release in juxtaglomerular cells. Kidney International . 1997

[4]

Knight B L,Perombelon Y F,Soutar A K et al.Catabolism of Lp (a) in familial hypercholesterolaemic subjects. Atherosclerosis . 1991

[5]

Steinberg D,Parthasarpby S,Carew T E et al.Beyond cholesterol modification of low density lipoprotein that increase its atherogenity. The New England Journal of Medicine . 1989

[6]

Wanner C,Rader D,Barren W et al.Elevated plasma Lp(a) in patients with the nephrotic syndrome. Annals of Internal Medicine . 1993

[7]

Ordonez J D,Robert H,Ellen K et al.The risk of coronary artery disease among patients with the nephrotic syndrome. Kidney International . 1990

[8]

Utermann G.The mysteries of lipoprotein (a). Science . 1989

[9]

Dahlen G H,Guyton J R,Arrar M et al.Association of level of lipoprotein (a), plasma lipids and other lipoproteins with coronary artery disease documented by angiography. Circulation . 1986

← 1 →