Phenotypicanalysisofthemedullary-typeCD4-CD8+thymocytesinmice

被引：0

作者：

TIAN Tian WANG Hongfang FENG Meifu CHEN Weifeng Department of Immunology Beijing Medical University Beijing China Institute of Zoology Chinese Academy of Sciences Beijing China Correspondence should be addressed to Chen Weifeng ^{[1
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机构：

来源：

ChineseScienceBulletin | 2000年 / 03期

关键词：

CD~4 CD8~+ medullary-type thymocytes; cell phenotype; phenotypic differentiation;

D O I：

暂无

中图分类号：

Q25 [细胞生理学];

学科分类号：

071009 ; 090102 ;

摘要：

<正> Phenotypic analysis of the medullary-type CD4 CD8+ (CD8SP) thymocytes has revealed phenotypic heterogeneity within this cell population. The phenotype of mature peripheral CD8+T cells is TCRαβ+CD3+Qa-2+HSA3G11 6C10 , whereas in the medullary-type CD8SP thymocytes, 20% are Qa-2+; 33%, HAS ; 30%, 3G11 ; and 70% are 6C10 . The disparate expression patterns of these four cell surface markers suggest that medullary-type CD8SP thymocytes may undergo phenotypic maturation process. According to the distribution of these four celi surface markers, six subgroups of CD8SP thymocytes have been identified. The precursor-progeny relationship along with developmental pathway is postulated as follows: 6C10+HSA+3G11 Qa-2 - 6C10+HSA+ 3G11+Qa-2 6C10 HSA+3G11+Qa-2 -6C10 HSA 3G11 +Qa-2 -6C10 HSA 3G11 Qa-2 -6C10 HA S 3G11 Qa-2+, the cells inthe last subgroup exit the thymus and home into periphery.

引用

页码：232 / 237

页数：6