Liver fat content determined by magnetic resonance imaging and spectroscopy

被引:1
作者
Fabian Springer [1 ]
Jürgen Machann [1 ]
Claus D Claussen [2 ]
Fritz Schick [1 ]
Nina F Schwenzer [1 ]
机构
[1] Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen
[2] Department of Diagnostic and Intervent ional Radiology, University Hospital Tübingen
关键词
Hepatic steatosis; Magnetic resonance imaging; Proton magnetic resonance spectroscopy; Lipids;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
1002 ; 100201 ;
摘要
Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALD, NAFLD is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations.
引用
收藏
页码:1560 / 1566
页数:7
相关论文
共 27 条
[1]   Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene [J].
Kantartzis, Konstantinos ;
Peter, Andreas ;
Machicao, Fausto ;
Machann, Juergen ;
Wagner, Silvia ;
Koenigsrainer, Ingmar ;
Koenigsrainer, Alfred ;
Schick, Fritz ;
Fritsche, Andreas ;
Haering, Hans-Ulrich ;
Stefan, Norbert .
DIABETES, 2009, 58 (11) :2616-2623
[2]   Abdominal adiposity and liver fat content 3 and 12 months after gastric banding surgery [J].
Heath, Madeleine L. ;
Kow, Lilian ;
Slavotinek, John P. ;
Valentine, Robin ;
Toouli, Jim ;
Thompson, Campbell H. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (06) :753-758
[3]  
Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance[J] . Nina F. Schwenzer,Fabian Springer,Christina Schraml,Norbert Stefan,Jürgen Machann,Fritz Schick.Journal of Hepatology . 2009 (3)
[4]   Parametric exploration of the liver by magnetic resonance methods [J].
Sijens, Paul E. .
EUROPEAN RADIOLOGY, 2009, 19 (11) :2594-2607
[5]  
The L162V Polymorphism of the Peroxisome Proliferator Activated Receptor Alpha Gene (PPARA) is not Associated with Type 2 Diabetes, BMI or Body Fat Composition[J] . G. Silbernagel,N. Stefan,M. Hoffmann,F. Machicao-Arano,J. Machann,F. Schick,B. Winkelmann,B. Boehm,H. H?ring,A. Fritsche,W. M?rz.Exp Clin Endocrinol Diabetes . 2009 (03)
[6]   Causes and Metabolic Consequences of Fatty Liver [J].
Stefan, Norbert ;
Kantartzis, Konstantinos ;
Haering, Hans-Ulrich .
ENDOCRINE REVIEWS, 2008, 29 (07) :939-960
[7]  
Role of Fatty Acids in the Pathogenesis of Obesity and Fatty Liver: Impact of Bariatric Surgery[J] . Elizabeth Verna,Paul Berk.Semin Liver Dis . 2008 (04)
[8]   Associates of change in liver fat content in the morbidly obese after laparoscopic gastric banding surgery [J].
Phillips, M. L. ;
Boase, S. ;
Wahlroos, S. ;
Dugar, M. ;
Kow, L. ;
Stahl, J. ;
Slavotinek, J. P. ;
Valentine, R. ;
Toouli, J. ;
Thompson, C. H. .
DIABETES OBESITY & METABOLISM, 2008, 10 (08) :661-667
[9]  
Spectroscopic imaging: Basic principles[J] . Antonin Skoch,Filip Jiru,Jürgen Bunke.European Journal of Radiology . 2008 (2)
[10]  
1 H MR spectroscopy of skeletal muscle, liver and bone marrow[J] . Jürgen Machann,Norbert Stefan,Fritz Schick.European Journal of Radiology . 2008 (2)