Searching for more effective HCV NS3 protease inhibitors via modification of corilagin

被引：0

作者：

WANG Yue YANG Xiaosheng LI Zhengquan ZHANG Wei CHEN Lirong and XU Xiaojie College of Chemistry and Molecular Engineering Peking University Beijing China ^{[100871
]}

The Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of Sciences Guiyang China ^{[550002
]}

机构：

来源：

Progress in Natural Science | 2005年 / 10期

关键词：

corilagin; synthesis; HCV NS3 serine protease; molecular docking;

D O I：

暂无

中图分类号：

R373 [人体病毒学（致病病毒）];

学科分类号：

100103 ; 100705 ;

摘要：

<正>Corilagin was seperated from extract of Phyllanthus urinaria L . and used as the precursor of inhibitors of hepatitis C virus (HCV) NS3 serine protease. Six derivatives were obtained through the chemical modification of corilagin and their structures were elucidated by the spectra analysis. Bioassay of these compounds showed that two of them had improved inhibitory efficiency than the precursor, with IC50 values of 2.28μmol/L and 1.52μmol/L, respectively. The binding mode of two active compounds with substrate bind ing site of HCV NS3 protease was also investigated by molecular docking method.

引用

页码：34 / 39

页数：6