Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities

被引：0

作者：

Na Gao

Zhi-Chun Shang

Pei Yu

Jie Luo

Kai-Li Jian

Ling-Yi Kong

Ming-Hua Yang

机构：

[1] StateKeyLaboratoryofNaturalMedicines,DepartmentofNaturalMedicinalChemistry,ChinaPharmaceuticalUniversity

来源：

Chinese Chemical Letters | 2017年 / 28卷 / 06期

关键词：

Penicillium brefeldianum; Alkaloids; Indoloditerpene; Indole-diketopiperazine; 13-Membered macrolide; Cytotoxicities;

D O I：

暂无

中图分类号：

O629.3 [生物碱];

学科分类号：

070303 ; 081704 ;

摘要：

One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isolated from the solid cultures of the endophytic fungus,Penicillium brefeidianum.The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism（CD） exciton chirality method.All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines.Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC50 values of 14.1 μmol/L and 35.5μmol/L,respectively.Compound 3 showed moderate activity against HepG2 cells with IC50 values of 36.6 μmol/L.

引用

页码：1194 / 1199

页数：6

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