A combination regimen by lopinave/litonawe (LPV/r), emtricitabine and tenofovir alafenamide fumarate (FTC/TAF) for treatment of novel coronavirus pneumonia (TARCoV)
被引:0
作者:
Jiang Hua
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机构:
Institute for Emergency and Disaster Medicine
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Jiang Hua
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Wang Yu
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机构:
Institute for Emergency and Disaster Medicine
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Wang Yu
[1
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Wang Kai
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h-index: 0
机构:
Institute for Emergency and Disaster Medicine
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Wang Kai
[1
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Yang Xingxiang
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机构:
Department of
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Yang Xingxiang
[7
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]
Zhang Jiancheng
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h-index: 0
机构:
Institute for Emergency and Disaster Medicine
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Zhang Jiancheng
[1
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Deng Hongfei
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h-index: 0
机构:
Institute for Emergency and Disaster Medicine
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Deng Hongfei
[1
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Wang Lu
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h-index: 0
机构:
Institute for Emergency and Disaster Medicine
Sichuan Provincial People''s Hospital
School of Medicine
University of Electronic Science and Technology of China
Chengdu
ChinaInstitute for Emergency and Disaster Medicine
Wang Lu
[1
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]
Zeng Jun
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h-index: 0
机构:Institute for Emergency and Disaster Medicine
Zeng Jun
机构:
[1] Institute for Emergency and Disaster Medicine
[2] Sichuan Provincial People''s Hospital
[3] School of Medicine
[4] University of Electronic Science and Technology of China
Novel coronavirus pneumonia;
Lopinave/Litonawe;
Emtricitabine and tenofovir alafenamide fumarate;
Survival rate;
Length of hospital stay;
D O I:
暂无
中图分类号:
R563.1 [肺炎];
学科分类号:
摘要:
Objective To explore the efficacy of a combination regimen by Lopinave/Litonawe (LPV/r), emtricitabine and tenofovir alafenamide fumarate (FTC/TAF) for the treatment of novel coronavirus pneumonia (NCP).Methods We design the protocol as a real world study, which includes two groups: prospective intervention cohort (T1) and historical control group (T2). For T1 group, ninety patients will be enrolled who are diagnosed as NCP. All patients in T1 group will receive standard therapies following the recommendation in the guidelines of National Commission of Health, and they will be administered an anti-virus regimen includes LPV/r and FTC/TAF. The T2 group will enroll patients who have received single regimen includes LPV/r. The major outcome is the survival rate of patients. Secondary outcomes are the time of seroconversion of RNA, ARDS progression rate and length of hospital stay.Conclusions The results of this real world study might provide clinical practitioners a high efficiency and fast antivirus regimen for NCP. In addition, the conduction of this study will accelerate screening for other new effective therapeutic method.
Complete genome characterisation of a novel coronavirus associated with severe humanrespiratory disease in Wuhan, China .2 Wu Fan,Zhao Su,Yu Bin,et al. . 2020
Complete genome characterisation of a novel coronavirus associated with severe humanrespiratory disease in Wuhan, China .2 Wu Fan,Zhao Su,Yu Bin,et al. . 2020