Scopariusols L–T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius

被引：1

作者：

JIANG HuaYi ^{[1
,2
,3
]}

LI XiaoNian ^{[2
]}

SUN HanDong ^{[2
]}

ZHANG HongBin ^{[1
]}

PUNO PemaTenzin ^{[2
]}

机构：

[1] Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University

[2] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

[3] University of Chinese Academy of Sciences

来源：

Chinese Journal of Natural Medicines | 2018年 / 16卷 / 06期

关键词：

Isodon scoparius; Ent-kaurane diterpenoids; X-ray diffraction; Cytotoxicity; Anti-inflammatory activity;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

Nine new ent-kaurane diterpenoids, named scopariusols L–T(1–9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 0.6 μmol·L-1.

引用

页码：456 / 464

页数：9

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