Overexpression of sterol carrier protein-2 mRNA in patients with cholesterol gallstones

被引：3

作者：

Nai-Qiang Cui

Shu-Kun Zhang

Yun-Feng Cui

Dong-Hua Li

Chang Chen and Xian-Zhong Wu Tianjin

China Institute of Acute Abdominal Diseases and Department of Surgery

机构：

来源：

Hepatobiliary & Pancreatic Diseases International | 2005年 / 01期

关键词：

SCP2 mRNA expression; lithogenic biles; cholesterol gallstone;

D O I：

暂无

中图分类号：

R575.6 [胆囊疾病];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Hypersecretion of biliary cholesterol is believed to be one of the important causes of lithogenic bile. Sterol carrier protein-2 ( SCP2 ) participates in choles- terol trafficking and metabolism and may play a key role in cholesterol gallstone formation. This study was undertaken to investigate the expression of liver SCP2 mRNA in pa- tients with cholesterol gallstone and those patients with non-cholesterol gallstone. METHODS: The expression of liver SCP2 mRNA was studi- ed in 36 patients with cholesterol gallstone and 30 patients with non-cholesterol gallstone by reverse transcription-poly- merase chain reaction (RT-PCR). RESULT: The expression of SCP2 mRNA was increased more significantly in patients with cholesterol gallstone than in patients with non-cholesterol gallstone. CONCLUSION: The SCP2 gene was overexpressed in pa- tients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.

引用

页码：117 / 120

页数：4

共 9 条

[1] 胆固醇结石与载脂蛋白B基因多态性的关系 [J].

所广军 ;

韩天权 ;

张圣道 .

中华实验外科杂志, 2000, (01) :25-26

[2] 上海闵行地区胆固醇结石病易患因素分析 [J].

顾建平 ;

黄桂余 ;

蒋兆彦 ;

蒋渝 ;

韩天权 ;

张圣道 .

中华实验外科杂志, 2000, (01) :23-24

[3]

Sterol carrier protein‐2:Not just for cholesterol any more[J] . Eric J. Murphy.Molecular and Cellular Biochemistry . 2002 (1)

[4] Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid [J].

Mukherji, M ;

Kershaw, NJ ;

Schofield, CJ ;

Wierzbicki, AS ;

Lloyd, MD .

CHEMISTRY & BIOLOGY, 2002, 9 (05) :597-605

[5]

Sterol carrier protein-2: structure reveals function[J] . N.J. Stolowich,A.D. Petrescu,H. Huang,G.G. Martin,A.I. Scott,F. Schroeder.Cellular and Molecular Life Sciences . 2002 (2)

[6] Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice [J].

Zanlungo, S ;

Amigo, L ;

Mendoza, H ;

Miquel, JF ;

Vío, C ;

Glick, JM ;

Rodríguez, A ;

Kozarsky, K ;

Quiñones, V ;

Rigotti, A ;

Nervi, F .

GASTROENTEROLOGY, 2000, 119 (06) :1708-1719

[7]

Hepatic cholesterol metabolism in patients with cholesterol gallstones: Enhanced intracellular transport of cholesterol[J] . T Ito,S Kawata,Y Imai,H Kakimoto,JM Trzaskos,Y Matsuzawa.Gastroenterology . 1996 (5)

[8]

Intermembrane cholesterol transfer: Role of sterol carrier proteins and phosphatidylserine[J] . Friedhelm Schroeder,Peter Butko,Ivan Hapala,Terrence J. Scallen.Lipids . 1990 (11)

[9]

Cholesterol enrichment enhances expression of sterol carrier protein 2: imp lications for its function in intracellular cholesterol trafficking .2 Kraemer R,Pomerantaz KB,Kesav S,et al. J Lip id Res . 1995

← 1 →