PD-1/PD-Ls与多发性硬化的相关性研究进展

被引:0
|
作者
洪香香
王毅飞
付锦
机构
[1] 哈尔滨医科大学附属第二医院神经内科
关键词
多发性硬化; 程序性死亡受体1/程序性死亡配体;
D O I
暂无
中图分类号
R744.51 [];
学科分类号
摘要
多发性硬化(multiple sclerosis, MS)是中枢神经系统(central nervous system, CNS)脱髓鞘性自身免疫病, 可表现为多种神经功能障碍, 具有高复发性、高致残性特点。目前MS发病机制尚不明确, 多数研究认为与异常免疫反应相关。程序性死亡受体1(programmed cell death 1, PD-1)属于共抑制分子, 与其配体(PD-1 ligands, PD-Ls)结合后, 在免疫反应中发挥负性调节作用。文章概述了PD-1/PD-Ls与MS的关系及其在MS发病机制中的作用。
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  • [11] Downregulation of Immunosuppressive Molecules, PD-1 and PD-L1 but not PD-L2, in the Patients with Multiple Sclerosis
    Javan, Mohammad Reza
    Aslani, Saeed
    Zamani, Mohammad Reza
    Rostamnejad, Javad
    Asadi, Milad
    Farhoodi, Mahdi
    Nicknam, Mohammad Hossein
    [J]. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2016, 15 (04) : 296 - 302
  • [12] Role of the innate and adaptive immune responses in the course of multiple sclerosis
    Hemmer, Bernhard
    Kerschensteiner, Martin
    Korn, Thomas
    [J]. LANCET NEUROLOGY, 2015, 14 (04): : 406 - 419
  • [13] PD-1 Interaction with PD-L1 but not PD-L2 on B-cells Mediates Protective Effects of Estrogen against EAE[J] . Bodhankar Sheetal,Galipeau Danielle,Vandenbark Arthur A,Offner Halina.Journal of clinical & cellular immunology . 2013 (3)
  • [14] Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β-oestradiol-receptor-positive B cells that up-regulate PD-1 on CD4+ Foxp3+ regulatory T cells
    Bodhankar, Sheetal
    Vandenbark, Arthur A.
    Offner, Halina
    [J]. IMMUNOLOGY, 2012, 137 (04) : 282 - 293
  • [15] Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis
    Pittet, Camille L.
    Newcombe, Jia
    Prat, Alexandre
    Arbour, Nathalie
    [J]. JOURNAL OF NEUROINFLAMMATION, 2011, 8
  • [16] The Majority of Infiltrating CD8 T Lymphocytes in Multiple Sclerosis Lesions is Insensitive to Enhanced PD-L1 Levels on CNS Cells
    Pittet, Camille L.
    Newcombe, Jia
    Antel, Jack P.
    Arbour, Nathalie
    [J]. GLIA, 2011, 59 (05) : 841 - 856
  • [17] Effects of interferon-beta on co-signaling molecules: upregulation of CD40, CD86 and PD-L2 on monocytes in relation to clinical response to interferon-beta treatment in patients with multiple sclerosis[J] . Wiesemann Elke,Deb Milani,Trebst Corinna,Hemmer Bernhard,Stangel Martin,Windhagen Anja.Multiple sclerosis (Houndmills, Basingstoke, England) . 2008 (2)
  • [18] Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response[J] . Karni Arnon,Abraham Michal,Monsonego Alon,Cai Guifang,Freeman Gordon J,Hafler David,Khoury Samia J,Weiner Howard L.Journal of immunology (Baltimore, Md. : 1950) . 2006 (6)
  • [19] Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis[J] . Zhu Bing,Guleria Indira,Khosroshahi Arezou,Chitnis Tanuja,Imitola Jaime,Azuma Miyuki,Yagita Hideo,Sayegh Mohamed H.,Khoury Samia J..The Journal of Immunology . 2006 (6)
  • [20] Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis[J] . Schreiner Bettina,Mitsdoerffer Meike,Kieseier Bernd C,Chen Lieping,Hartung Hans-Peter,Weller Michael,Wiendl Heinz.Journal of neuroimmunology . 2004 (1-2)