Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology

被引：3
作者：
Tianying Xing [1 ,2 ]
Huiying He [1 ]
机构：
[1] Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center
[2] Department of Urology, Peking University Third Hospital
来源：
ChineseJournalofCancerResearch | 2016年 / 28卷 / 01期
关键词：
DNA methylation; histone modification; micro RNA; long noncoding RNA; clear cell renal cell carcinoma(cc RCC);
D O I：
暂无
中图分类号：
R737.11 [肾、肾盂肿瘤];
学科分类号：
100214 ;
摘要：
Clear cell renal cell carcinoma(cc RCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, micro RNAs and recently identified long noncoding RNAs in the development and progression of cc RCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with cc RCCs. With the developed highthroughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of cc RCC.
引用
收藏
页码：80 / 91
页数：12
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