Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology

被引：3

作者：

Tianying Xing ^{[1
,2
]}

Huiying He ^{[1
]}

机构：

[1] Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center

[2] Department of Urology, Peking University Third Hospital

来源：

ChineseJournalofCancerResearch | 2016年 / 28卷 / 01期

关键词：

DNA methylation; histone modification; micro RNA; long noncoding RNA; clear cell renal cell carcinoma(cc RCC);

D O I：

暂无

中图分类号：

R737.11 [肾、肾盂肿瘤];

学科分类号：

100214 ;

摘要：

Clear cell renal cell carcinoma(cc RCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, micro RNAs and recently identified long noncoding RNAs in the development and progression of cc RCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with cc RCCs. With the developed highthroughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of cc RCC.

引用

页码：80 / 91

页数：12

共 41 条

[1] Enhancer of zeste homolog 2 (EZH2) promotes tumour cell migration and invasion via epigenetic repression of E-cadherin in renal cell carcinoma
Liu, Li
Xu, Zhibing
Zhong, Lei
Wang, Hang
Jiang, Shuai
Long, Qilai
Xu, Jiejie
Guo, Jianming
[J]. BJU INTERNATIONAL, 2016, 117 (02) : 351 - 362
[2] Cancer statistics, 2015[J] . Rebecca L. Siegel,Kimberly D. Miller,Ahmedin Jemal.CA: A Cancer Journal for Clinicians . 2015 (1)
[3] Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells
Wu, Yuanhao
Liu, Junfeng
Zheng, Yin
You, Li
Kuang, Dingwei
Liu, Te
[J]. TUMOR BIOLOGY, 2014, 35 (12) : 11887 - 11894
[4] Low Expression of miR-126 is a Prognostic Marker for Metastatic Clear Cell Renal Cell Carcinoma[J] . Heba WZ. Khella,Andreas Scorilas,Roy Mozes,Lorna Mirham,Evi Lianidou,Sergey N. Krylov,Jason Y. Lee,Michael Ordon,Robert Stewart,Michael A.S. Jewett,George M. Yousef.The American Journal of Pathology . 2014
[5] miR-210 is a Prognostic Marker in Clear Cell Renal Cell Carcinoma[J] . Sara Samaan,Heba W.Z. Khella,Andrew Girgis,Andreas Scorilas,Evi Lianidou,Manal Gabril,Sergey N. Krylov,Michael Jewett,Georg A. Bjarnason,Hala El-said,George M. Yousef.The Journal of Molecular Diagnostics . 2014
[6] The miR21/10b ratio as a prognostic marker in clear cell renal cell carcinoma
Fritz, Helena K. M.
Lindgren, David
Ljungberg, Borje
Axelson, Hakan
Dahlback, Bjorn
[J]. EUROPEAN JOURNAL OF CANCER, 2014, 50 (10) : 1758 - 1765
[7] Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing[J] . Gabriel G. Malouf,Jianping Zhang,Ying Yuan,Eva Compérat,Morgan Rouprêt,Olivier Cussenot,Yunxin Chen,Erika J. Thompson,Nizar M. Tannir,John N. Weinstein,Vicente Valero,David Khayat,Jean-Philippe Spano,Xiaoping Su.Molecular Oncology . 2014
[8] Expression of the Tumor Suppressive miRNA-23b/27b Cluster Is a Good Prognostic Marker in Clear Cell Renal Cell Carcinoma[J] . Tomoaki Ishihara,Naohiko Seki,Satoru Inoguchi,Hirofumi Yoshino,Shuichi Tatarano,Yasutoshi Yamada,Toshihiko Itesako,Yusuke Goto,Rika Nishikawa,Masayuki Nakagawa,Hideki Enokida.The Journal of Urology . 2014
[9] Differential expression of microRNA501-5p affects the aggressiveness of clear cell renal carcinoma[J] . Alessandra Mangolini,Anna Bonon,Stefano Volinia,Giovanni Lanza,Roberto Gambari,Paolo Pinton,Gian Rosario Russo,Laura del Senno,Lucio Dell’Atti,Gianluca Aguiari.FEBS Open Bio . 2014
[10] microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion
Bera, Amit
Das, Falguni
Ghosh-Choudhury, Nandini
Kasinath, Balakuntalam S.
Abboud, Hanna E.
Choudhury, Goutam Ghosh
[J]. EXPERIMENTAL CELL RESEARCH, 2014, 328 (01) : 99 - 117

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