Optimization of multicomponent solvent selection in high-performance liquid chromatography using a statistical method

被引：0
作者：
WANG
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来源：
Chinese Journal of Chemistry | 1991年 / 03期
关键词：
Optimization of multicomponent solvent selection in high-performance liquid chromatography using a statistical method; high;
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摘要：
A computer-assisted method is presented for optimization of multicomponent solventmobile phase selection for separation of O-ethyl-N-isopropyl phosphoro（thioureido）thioates inreversed-phase HPLC and four geometric isomers of pesticides Decis in normal-phase HPLC.Themethod is based on Snyder’s solvent selection triangle concept using a statistical method.Theoptimization of the separation over the experimental region is based on a special polynomial esti-mation from seven experimental runs,and resolution（R）is used as the selection criterion.Excellentagreement was obtained between predicted data and experimental results.
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页码：222 / 230
页数：9
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  • [1] Computer-assisted transposition of conditions in high-performance thin-layer chromatography to high-performance liquid chromatography for the separation of pesticides[J] . Qin-Sun Wang,Ru-Yu Gao,Heng-Yan Wang.Chromatographia . 1989 (5-6)
  • [2] An improved optimization procedure for the selection of mixed mobile phases in reversed phase liquid chromatography[J] . A. C. J. H. Drouen,H. A. H. Billiet,P. J. Schoenmakers,L. Galan.Chromatographia . 1982 (1)
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