circular RNA与肿瘤

被引:0
|
作者
王香琛 [1 ]
张雅芳 [2 ]
张建国 [3 ]
机构
[1] 黑龙江中医药大学基础医学院
[2] 哈尔滨医科大学人体解剖学教研室
[3] 哈尔滨医科大学附属第二医院乳腺外科
关键词
circular RNA; 分子标记物;
D O I
10.16695/j.cnki.1006-2947.2019.04.035
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
circular RNA(circRNA)是内源性RNA在剪切过程中产生的一种不具有3'帽和5'尾的由RNA共价连接形成的单链连续环状RNA。circRNA可与microRNA(miRNA)结合发挥miRNA海绵的作用,通过改变miRNA的表达水平影响多种肿瘤细胞的增殖、侵袭等生物学行为。多种circRNA在肿瘤组织中表达异常,并与肿瘤分期、转移等临床参数相关,提示circRNA可作为肿瘤的分子标记物。此外,circRNA在肿瘤抵抗放疗和化疗方面一定的作用。
引用
收藏
页码:484 / 486+490 +490
页数:4
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