Evaluations of dielectric property and drug release profile of 5-FU patches based on plasma charged electrets

被引：0

作者：

苑旺 ^{[1
]}

梁合鹃 ^{[1
]}

黄平 ^{[1
]}

安晓强 ^{[2
]}

江键 ^{[1
]}

崔黎丽 ^{[2
]}

机构：

[1] Department of Physics and Mathematics,College of Basic Medical Sciences,Second Military Medical University

[2] Department of Inorganic Chemistry,School of Pharmacy,Second Military Medical University

来源：

Plasma Science and Technology | 2018年 / 05期

关键词：

electret; hypertrophic scar; thermally stimulated discharge current; 5-fluorouracil; patch; piezoelectric coefficient;

D O I：

暂无

中图分类号：

O53 [等离子体物理学];

学科分类号：

070204 ;

摘要：

In the present study,the electret 5-fluorouracil patch was developed,the effective surface potential,piezoelectric coefficient d33,open-circuit thermally stimulated discharge(TSD) current spectra and shear adhesion of the patch were measured.The drug release profile of the patch was determined by using high performance liquid chromatography method.A stable potential difference which was positively dependent on the surface potential of the electret was generated on two sides of the patch.The measurements of d33 coefficient,TSD current spectra and adhesion performance showed that the electrostatic field of the electret could cause polarization and cohesive strength decreasing of the matrix molecules,change the distribution and interaction of the drug molecules in patch,therefore to increase the release of drug from the transdermal patch.

引用

页码：114 / 120

页数：7

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