RNA-binding proteins in neurological diseases

被引：0

作者：

ZHOU HuaLin ^{[1
]}

MANGELSDORF Marie ^{[2
]}

LIU JiangHong ^{[1
]}

ZHU Li ^{[1
]}

WU Jane Y ^{[1
,3
]}

机构：

[1] Institute of Biophysics,Chinese Academy of Sciences

[2] Queensland Brain Institute, The University of Queensland,Brisbane

[3] Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine

来源：

Science China(Life Sciences) | 2014年 / 57卷 / 04期

关键词：

RNA-binding proteins; post-transcriptional regulation; neurological diseases;

D O I：

暂无

中图分类号：

R742 [脑部疾病];

学科分类号：

1002 ;

摘要：

Emerging studies support that RNA-binding proteins(RBPs)play critical roles in human biology and pathogenesis.RBPs are essential players in RNA processing and metabolism,including pre-mRNA splicing,polyadenylation,transport,surveillance,mRNA localization,mRNA stability control,translational control and editing of various types of RNAs.Aberrant expression of and mutations in RBP genes affect various steps of RNA processing,altering target gene function.RBPs have been associated with various diseases,including neurological diseases.Here,we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2,HuR/HuB/HuC/HuD,TDP-43,Fus,Rbfox1/Rbfox2,QKI and FMRP,discussing their function and roles in human diseases.

引用

页码：432 / 444

页数：13

共 55 条

[1]

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD–ALS spectrum disorders[J] . Jonathan Janssens,Christine Van Broeckhoven.Human Molecular Genetics . 2013 (R1)

[2]

Take the （RN）A-train: Localization of mRNA to the endoplasmic reticulum[J] . Orit Hermesh,Ralf-Peter Jansen.BBA - Molecular Cell Research . 2013

[3]

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention[J] . Christopher J. Donnelly,Ping-Wu Zhang,Jacqueline T. Pham,Aaron R. Haeusler,Nipun A. Mistry,Svetlana Vidensky,Elizabeth L. Daley,Erin M. Poth,Benjamin Hoover,Daniel M. Fines,Nicholas Maragakis,Pentti J. Tienari,Leonard Petrucelli,Bryan J. Traynor,Jiou Wang,Frank Rigo,C. Frank Bennett,Seth Blackshaw,Rita Sattler,Jeffrey D. Rothstein.Neuron . 2013 (4)

[4] Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain [J].

Narayanan, Ramesh K. ;

Mangelsdorf, Marie ;

Panwar, Ajay ;

Butler, Tim J. ;

Noakes, Peter G. ;

Wallace, Robyn H. .

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 2013, 14 (04) :252-260

[5] hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations [J].

Mori, Kohji ;

Lammich, Sven ;

Mackenzie, Ian R. A. ;

Forne, Ignasi ;

Zilow, Sonja ;

Kretzschmar, Hans ;

Edbauer, Dieter ;

Janssens, Jonathan ;

Kleinberger, Gernot ;

Cruts, Marc ;

Herms, Jochen ;

Neumann, Manuela ;

Van Broeckhoven, Christine ;

Arzberger, Thomas ;

Haass, Christian .

ACTA NEUROPATHOLOGICA, 2013, 125 (03) :413-423

[6]

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation[J] . Carolyn J. Decker,Roy Parker.Cold Spring Harbor Perspectives in Biology . 2012 (9)

[7] Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis [J].

Couthouis, Julien ;

Hart, Michael P. ;

Erion, Renske ;

King, Oliver D. ;

Diaz, Zamia ;

Nakaya, Tadashi ;

Ibrahim, Fadia ;

Kim, Hyung-Jun ;

Mojsilovic-Petrovic, Jelena ;

Panossian, Saarene ;

Kim, Cecilia E. ;

Frackelton, Edward C. ;

Solski, Jennifer A. ;

Williams, Kelly L. ;

Clay-Falcone, Dana ;

Elman, Lauren ;

McCluskey, Leo ;

Greene, Robert ;

Hakonarson, Hakon ;

Kalb, Robert G. ;

Lee, Virginia M. Y. ;

Trojanowski, John Q. ;

Nicholson, Garth A. ;

Blair, Ian P. ;

Bonini, Nancy M. ;

Van Deerlin, Vivianna M. ;

Mourelatos, Zissimos ;

Shorter, James ;

Gitler, Aaron D. .

HUMAN MOLECULAR GENETICS, 2012, 21 (13) :2899-2911

[8] Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability [J].

Ince-Dunn, Gulayse ;

Okano, Hirotaka J. ;

Jensen, Kirk B. ;

Park, Woong-Yang ;

Zhong, Ru ;

Ule, Jernej ;

Mele, Aldo ;

Fak, John J. ;

Yang, ChingWen ;

Zhang, Chaolin ;

Yoo, Jong ;

Herre, Margaret ;

Okano, Hideyuki ;

Noebels, Jeffrey L. ;

Darnell, Robert B. .

NEURON, 2012, 75 (06) :1067-1080

[9]

RNA‐binding proteins in neurodegenerative disease: TDP‐43 and beyond[J] . Keith A.Hanson,Sang HwaKim,Randal S.Tibbetts.WIREs RNA . 2012 (2)

[10] Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination [J].

Skourti-Stathaki, Konstantina ;

Proudfoot, Nicholas J. ;

Gromak, Natalia .

MOLECULAR CELL, 2011, 42 (06) :794-805

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