Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

被引:2
作者
RAGUNATHAN Irulappan
PANNEERSELVAM Natarajan
机构
[1] Research Centre and Postgraduate Studies in Botany the Madura College Madurai-625 011 Tamil Nadu India
[2] Research Centre and Postgraduate Studies in Botany the Madura College Madurai-625 011 Tamil Nadu India
关键词
Chromosomal aberrations; Sodium azide; Genotoxicity; Allium cepa;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
1008 ;
摘要
Turmeric has long been used as a spice and food colouring agent in Asia. In the present investigation, the antimutagenic potential of curcumin was evaluated in Allium cepa root meristem cells. So far there is no report on the biological properties of curcumin in plant test systems. The root tip cells were treated with sodium azide at 200 and 300 μg/ml for 3 h and curcumin was given at 5, 10 and 20 μg/ml for 16 h, prior to sodium azide treatment. The tips were squashed after colchicine treatment and the cells were analyzed for chromosome aberration and mitotic index. Curcumin induces chromosomal aberration in Allium cepa root tip cells in an insignificant manner, when compared with untreated control. Sodium azide alone induces chromosomal aberrations significantly with increasing concentrations. The total number of aberrations was significantly reduced in root tip cells pretreated with curcumin. The study reveals that curcumin has antimutagenic potential against sodium azide induced chromosomal aberrations in Allium cepa root meristem cells. In addition, it showed mild cytotoxicity by reducing the percentage of mitotic index in all curcumin treated groups, but the mechanism of action remains unknown. The antimutagenic potential of curcumin is effective at 5 μg/ml in Allium cepa root meristem cells.
引用
收藏
页码:470 / 475
页数:6
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