Claudin家族基因剔除小鼠表型的研究进展附视频

被引：3

作者：

杨慧 ^{[1
]}

王晓楠 ^{[1
]}

丁磊 ^{[1
]}

封国生 ^{[2
]}

机构：

[1] 首都医科大学附属北京世纪坛医院肿瘤中心

[2] 首都医科大学附属北京朝阳医院普外科

来源：

医学综述 | 2015年 / 18期

关键词：

紧密连接; 密封蛋白; 基因剔除; 小鼠; 表型;

D O I：

暂无

中图分类号：

R346 [];

学科分类号：

摘要：

密封蛋白(Claudin)是细胞间紧密连接的骨架蛋白,参与维持紧密连接的各种功能,其异常表达可破坏上皮细胞及内皮细胞的结构,导致其功能严重受损。近年来,关于Claudin基因不同生理作用的研究越来越受到人们的关注,基因剔除技术将在整体动物水平研究基因功能成为可能。该文就Claudin家族基因剔除后的小鼠表型进行综述,旨在了解Claudin基因的生理功能。

引用

页码：3265 / 3268

页数：4

共 12 条

[1] Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice
Sugawara, Tomoko
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[2] Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis
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Lau, K-H William
Wergedal, Jon E.
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[J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (07) : 1553 - 1565
[4] Deficiency of Claudin-18 Causes Paracellular H + Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice[J] . Daisuke Hayashi,Atsushi Tamura,Hiroo Tanaka,Yuji Yamazaki,Shin Watanabe,Koya Suzuki,Kazuo Suzuki,Kazuhiro Sentani,Wataru Yasui,Hiromi Rakugi,Yoshitaka Isaka,Sachiko Tsukita.Gastroenterology . 2012 (2)
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[6] Loss of Claudin-15, but Not Claudin-2, Causes Na + Deficiency and Glucose Malabsorption in Mouse Small Intestine[J] . Atsushi Tamura,Hisayoshi Hayashi,Mitsunobu Imasato,Yuji Yamazaki,Asuka Hagiwara,Masami Wada,Tetsuo Noda,Mitsuhiro Watanabe,Yuichi Suzuki,Sachiko Tsukita.Gastroenterology . 2011 (3)
[7] Claudin Family of Proteins and Cancer: An Overview[J] . Amar B. Singh,Ashok Sharma,Punita Dhawan,Ala-Eddin Al Moustafa.Journal of Oncology . 2010
[8] Tight junction defects in patients with atopic dermatitis[J] . Anna De Benedetto,Nicholas M. Rafaels,Laura Y. McGirt,Andrei I. Ivanov,Steve N. Georas,Chris Cheadle,Alan E. Berger,Kunzhong Zhang,Sadasivan Vidyasagar,Takeshi Yoshida,Mark Boguniewicz,Tissa Hata,Lynda C. Schneider,Jon M. Hanifin,Richard L. Gallo,Natalija Novak,Stephan Weidinger,Terri H. Beaty,Donald Y.M. Leung,Kathleen C. Barnes,Lisa A. Beck.The Journal of Allergy and Clinical Immunology . 2010 (3)
[9] Alteration of Tight Junction Proteins Is an Early Event in Psoriasis[J] . Nina Kirschner,Claudia Poetzl,Peter von den Driesch,Ewa Wladykowski,Ingrid Moll,Martin J. Behne,Johanna M. Brandner.The American Journal of Pathology . 2009 (3)
[10] Megaintestine in Claudin-15–Deficient Mice[J] . Atsushi Tamura,Yuka Kitano,Masaki Hata,Tatsuya Katsuno,Kazumasa Moriwaki,Hiroyuki Sasaki,Hisayoshi Hayashi,Yuichi Suzuki,Tetsuo Noda,Mikio Furuse,Shoichiro Tsukita,Sachiko Tsukita.Gastroenterology . 2008 (2)

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