HIGH EXPRESSION OF HUMAN FACTOR IX cDNA DRIVEN BY HCMV PROMOTER IN MAMMALIAN CELLS

<正> Ⅰ. INTRODUCTION Clotting factor Ⅸ is an essential member in the intrinsic clotting pathway, and the deficiency of factor Ⅸ may cause hemophilia B. An important subject on gene therapy for hemophilia B is to increase the protein products of factor Ⅸ in human cells. In our earlier studies, we have constructed several recombinant retroviral vectors with factor Ⅸ