<正> Objective: Overexpression of the membraneepidermal growth factor receptor (EGFR) in humantumor cells predicts for poor prognosis. Hence, weexperimentally investigated the effects of humanEGFR to the malignant phenotype in humen breastcancer cell line MDA-MB-231 and humannasopharyngeal carcinoma cell line CNE-2. Methods: