含哌嗪化合物作为受体配体的研究进展

被引：12

作者：

甘淋玲 ^{[1
]}

蔡佳利 ^{[2
]}

周成合 ^{[1
,2
]}

机构：

[1] 西南大学药学院

[2] 西南大学化学化工学院

来源：

中国药学杂志 | 2009年 / 44卷 / 18期

关键词：

哌嗪; 多巴胺受体; 5-羟色胺受体; α1肾上腺素受体; 抗精神病药; 抗抑郁;

D O I：

暂无

中图分类号：

R91 [药物基础科学];

学科分类号：

1007 ;

摘要：

目的综述了含哌嗪化合物作为受体配体的研究进展。方法综合国内外文献阐述了含哌嗪化合物作为多巴胺(DA)受体、5-羟色胺(5-HT)受体、α1肾上腺素受体(α1-AR)、黑皮质素-4受体(MC4R)以及σ受体配体等方面的最新研究概况。结果与结论含哌嗪化合物作为相应的受体配体具有广泛的生物活性,是目前研究开发的活跃领域之一,随着研究的不断深入,将有越来越多选择性高、药动学性质好的含哌嗪环药物应用于临床。

引用

页码：1361 / 1368

页数：8

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