Synthesis,Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae

被引：0

作者：

张敬一 ^{[1
]}

钟涵宇 ^{[2
]}

史国兵 ^{[1
]}

机构：

[1] Department of Pharmacy, General Hospital of Shenyang Military Command

[2] Department of Pharmacy, First Affiliated Hospital,China Medical University

来源：

Chinese Journal of Structural Chemistry | 2014年 / 06期

关键词：

3; 4; 5-trimethoxyphenyl; synthesis; crystal structure; antiproliferative activities;

D O I：

10.14102/j.cnki.0254-5861.2014.06.012

中图分类号：

TQ463 [有机化合物药物的生产]; O741.6 [];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ; 1007 ;

摘要：

Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4(CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4), β = 111.9010(10)o, V = 2072.36(8)3, Z = 4, C22H24NO6, Mr = 398.42, Dc = 1.277 Mg/cm3, F(000) = 844, λ(MoKα) = 1.54178 , μ = 0.770 mm–1, R = 0.0546 and wR = 0.1889 for 3319 observed reflections(I > 2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.

引用

页码：876 / 880

页数：5

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