钠通道NaV1.9与疼痛的研究进展

被引:0
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作者
何询 [1 ]
周熙 [2 ]
机构
[1] 深圳未名新鹏生物医药有限公司
[2] 湖南师范大学生命科学学院动物多肽药物创制国家地方联合工程实验室
关键词
钠通道; NaV1.9; 疼痛; 镇痛药物; 药理学;
D O I
暂无
中图分类号
R402 [];
学科分类号
摘要
电压门控钠通道NaV1.9特异性表达于外周伤害感受器,在神经电信号产生和传导的过程中扮演着重要角色。动物模型和临床遗传学研究表明,其在炎性疼痛、神经性疼痛和冷痛中具有重要作用,是一个潜在的镇痛药物研发靶点。本文从NaV1.9的表达定位、生理学特性、疼痛动物模型研究、临床相关疼痛疾病研究和药理学研究这几个方面对NaV1.9与疼痛关系进行综述,探讨靶向镇痛药物开发,为深入研究Nav1.9在疼痛中的重要角色提供参考。
引用
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页码:496 / 500
页数:5
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