A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs

被引：0
|
作者：
Weiye Chen [1 ]
Dongming Zhao [1 ]
Xijun He [2 ]
Renqiang Liu [1 ]
Zilong Wang [1 ]
Xianfeng Zhang [2 ]
Fang Li [1 ]
Dan Shan [1 ]
Hefeng Chen [1 ]
Jiwen Zhang [1 ]
Lulu Wang [1 ]
Zhiyuan Wen [1 ]
Xijun Wang [1 ]
Yuntao Guan [2 ]
Jinxiong Liu [1 ]
Zhigao Bu [1 ,2 ]
机构：
[1] State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences
[2] National High Containment Laboratory for Animal Diseases Control and Prevention
来源：
Science China(Life Sciences) | 2020年 / 05期
基金：
国家重点研发计划;
关键词：
African swine fever; vaccine; safety; protective efficacy; pig;
D O I：
暂无
中图分类号：
S852.4 [家畜免疫学];
学科分类号：
090602 ;
摘要：
African swine fever(ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV, and as such is expected to play an important role in controlling the spread of ASFV.
引用
收藏
页码：623 / 635
页数：13
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