A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs

被引：0

作者：

Weiye Chen ^{[1
]}

Dongming Zhao ^{[1
]}

Xijun He ^{[2
]}

Renqiang Liu ^{[1
]}

Zilong Wang ^{[1
]}

Xianfeng Zhang ^{[2
]}

Fang Li ^{[1
]}

Dan Shan ^{[1
]}

Hefeng Chen ^{[1
]}

Jiwen Zhang ^{[1
]}

Lulu Wang ^{[1
]}

Zhiyuan Wen ^{[1
]}

Xijun Wang ^{[1
]}

Yuntao Guan ^{[2
]}

Jinxiong Liu ^{[1
]}

Zhigao Bu ^{[1
,2
]}

机构：

[1] State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences

[2] National High Containment Laboratory for Animal Diseases Control and Prevention

来源：

Science China(Life Sciences) | 2020年 / 05期

基金：

国家重点研发计划;

关键词：

African swine fever; vaccine; safety; protective efficacy; pig;

D O I：

暂无

中图分类号：

S852.4 [家畜免疫学];

学科分类号：

090602 ;

摘要：

African swine fever(ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV, and as such is expected to play an important role in controlling the spread of ASFV.

引用

页码：623 / 635

页数：13

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