Effect of quercetin and aspirin on platelet-neutrophil interaction

被引：0
|
作者：
林勇
高存记
于晓霞
茆挺
汪钟
机构：
[1] 中国医学科学院
[2] 中国协和医科大学基础医学研究所药理学研究室
来源：
中国药理学与毒理学杂志 | 1999年 / 02期
关键词：
血小板粘附; 血小板聚集; 中性粒细胞; 槲皮素; 阿司匹林;
D O I：
暂无
中图分类号：
R965.1 [药物筛选和实验模型];
学科分类号：
100602 ; 100706 ;
摘要：
采用血小板聚集及血小板与中性粒细胞形成玫瑰花结试验探讨槲皮素及阿司匹林对血小板与中性粒细胞相互作用的影响．结果表明，家兔中性粒细胞可抑制ＡＤＰ诱导的血小板聚集，槲皮素（０．３－１００μｍｏｌ·Ｌ－１）及阿司匹林（０．４－３．３ｍｍｏｌ·Ｌ－１）可增加中性粒细胞对血小板的抑制作用．当中性粒细胞被乙酸肉豆寇佛波醇（ＰＭＡ１００μｇ·Ｌ－１）激活时，此抑制作用消失．槲皮素（３μｍｏｌ·Ｌ－１）可对抗ＰＭＡ激活中性粒细胞．即使无中性粒细胞存在，阿司匹林亦可抑制血小板的聚集，但单独槲皮素却不抑制血小板聚集．槲皮素（３－３００μｍｏｌ·Ｌ－１）及阿司匹林（０．４－３．３ｍｍｏｌ·Ｌ－１）可浓度相关性地抑制凝血酶激活的血小板与中性粒细胞的粘附．
引用
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页码：19 / 23
页数：5
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