Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C-H bond activation

被引：0
作者：
Miao-Miao Chen [1 ]
Ling-Yan Shao [1 ]
Li-Jun Lun [2 ]
Yu-Liang Wu [2 ]
Xiao-Pan Fu [1 ]
Ya-Fei Ji [1 ]
机构：
[1] School of Pharmacy, East China University of Science & Technology
[2] Shandong Keyuan Pharmaceutical Co., Ltd., Shandong Shanghe Economic Development Zone
来源：
Chinese Chemical Letters | 2019年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Palladium-catalysis; Late-stage functionalization; AroYlation; Fully substituted pyrazoles; C-H bond activation; Cyclopalladated intermediate;
D O I：
暂无
中图分类号：
O621.251 [];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed late-stage aroylation of 4-methyl-1,5-diaryl-lH-pyrazole-3-carboxylates has been developed via direct and exclusive mono-Csp;-H bond activation with broad substrate scope and good functional group tolerance. A dual-core dimeric palladacycle is confirmed by X-ray single crystal crystallography, and probably serves as an active species in the catalytic cycle.
引用
收藏
页码：702 / 706
页数：5
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