Serum level of TSGF,CA242 and CA19-9 in pancreatic cancer

AIM:To establish a method to detect the expression of thetumor specific growth factor TSGF,CA242 and CA19-9 in serumand evaluate their value in diagnosis of pancreatic cancer.METHODS:ELISA and Biochemical colorimetric assay wereused to detect the serum content of TSGF,CA242 andCA19-9 in 200 normal cases,52 pancreatitis patients and96 pancreatic cancer patients.RESULTS:The positive likelihood ratios of TSGF,CA242and CA19-9 were 5.4,12.6 and 6.3,respectively,and theirnegative likelihood ratios were 0.10,0.19 and 0.17,respectively.With single tumor marker diagnosed pancreaticcancer,the highest sensitivity and specificity of TSGF were91.6% and 93.5%.In combined test with 3 markers,whenall of them were positive,the sensitivity changed to 77.0%and the specificity and the positive predictive value were100%.The levels of TSGF and CA242 were significantly higherin the patients with pancreatic cancer of head than those inthe patients with pancreatic cancer of body,tail and wholepancreas,but the expression of CA19-9 had no correlationwith the positions of the pancreatic cancer.The sensitivityof TSGF,CA242 and CA19-9 was increased with the progressin stages of pancreatic cancer.In stage Ⅰ,the sensitivity ofTSGF was markedly higher than CA242 and CA19-9.CONCLUSION:The combined use of TSGF,CA242 and CA19-9 expressions can elevate the specificity for pancreatic cancerdiagnosis.And it shows that it plays an important role todifferentiate positions and tissue typing.It is a forepartdiagnosis for the pancreatic cancer by combination checking.There is very important correlation between the three markersand the pancreatic cancer.