Synthesis,Crystal Structure and Bioactivity of 1-(3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-phenethyl)-4-phenylpiperidin-4-ol

被引：0

作者：

许星杰 ^{[1
]}

徐未 ^{[1
]}

陈洪 ^{[1
]}

邵斌豪 ^{[1
]}

机构：

[1] Pharmaceutical Research Center, Guangzhou Medical University

来源：

结构化学 | 2015年 / 34卷 / 12期

关键词：

crystal structure; phenylpiperidin; prostate cancer; C-H…π interactions; synthesis;

D O I：

10.14102/j.cnki.0254-5861.2011-0787

中图分类号：

O626 [杂环化合物]; TQ460.1 [基础理论];

学科分类号：

摘要：

The title compound l-(3-(（benzo[d][l,3]dioxol-5-yloxy）methyl)phenethyl)-4-phenylpiperidin-4-ol(4,C;H;NO;,M;= 431.51) was synthesized by a four-step reaction and characterized by;H NMR,;3C NMR,elemental analysis and single-crystal X-ray diffraction.The crystal is of triclinic,space group P1 with a= 5.8033（12）,b= 10.705（2）,c= 18.393（4） A,α =83.44（3）,β = 82.71（3）,γ = 88.88（3）°,V= 1126.0（4） A;,Z= 1,D;= 1.273 g/cm3,S = 1.070,μ =0.681 mm;,F（000） = 460,R = 0.0618 and wR = 0.1619 for 6452 observed reflections with I > 2σ（I）.Geometry conformations revealed that the dihedral angle between benzodioxole and aromatic planes contributed to the formation of C-H…π interactions.Hydrogen bonds and van der waals interactions were observed to stabilize the three-dimensional packing structure.The compound showed a moderate inhibitory activity against the prostate cancer cells.

引用

页码：1813 / 1818

页数：6

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