近红外荧光染料的结构、性质及生物荧光成像应用

被引：16

作者：

王晓驰

常刚

曹瑞军

孟令杰

机构：

[1] 西安交通大学理学院化学系

来源：

化学进展 | 2015年 / 27卷 / 07期

关键词：

近红外; 有机荧光染料; 荧光成像; 功能化;

D O I：

暂无

中图分类号：

TQ617.3 [荧光、磷光染料];

学科分类号：

0817 ;

摘要：

近红外荧光生物成像技术由于具有深的组织穿透性、低背景荧光干扰、最小生物样本光损伤等特点引起人们越来越多的关注。开发高荧光效率、低毒性的近红外荧光染料是近红外荧光成像技术发展的关键所在。本文综述了五类主要的有机近红外荧光染料(菁类、BODIPY类、罗丹明类、方酸类、卟啉类)的研究进展,重点分析其结构与光学性质等构效关系,为近红外荧光染料的设计和制备提供指导。另外,总结了有机近红外荧光材料功能化修饰的主要方法以改善生物相容性、靶向性能等,最后对近红外荧光染料存在的主要问题以及未来的热点方向进行了分析和展望。

引用

页码：794 / 805

页数：12

共 11 条

[1]

Near-infrared aminocyanine dyes: synthesis, optical properties, and application to the preparation of fluorescent microspheres[J] . Liang Yu,Tingting Li,Qiuling Wang,Lei Li,Ligong Chen.Research on Chemical Intermediates . 2014 (4)

[2] Comparison of a series of hydrophilic squaraine and cyanine dyes for use as biological labels [J].

Markova, Larysa I. ;

Terpetschnig, Ewald A. ;

Patsenker, Leonid D. .

DYES AND PIGMENTS, 2013, 99 (03) :561-570

[3] Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model [J].

Ryu, Ju Hee ;

Shin, Jung-Youn ;

Kim, Sun Ah ;

Kang, Sun-Woong ;

Kim, Hyunjoon ;

Kang, Seokyung ;

Choi, Kuiwon ;

Kwon, Ick Chan ;

Kim, Byung-Soo ;

Kim, Kwangmeyung .

BIOMATERIALS, 2013, 34 (28) :6871-6881

[4]

Rhodamine 800 as reference substance for fluorescence quantum yield measurements in deep red emission range[J] . A. Alessi,M. Salvalaggio,G. Ruzzon.Journal of Luminescence . 2013

[5] Near-Infrared Fluorescent Silica/Porphyrin Hybrid Nanorings for In Vivo Cancer Imaging [J].

Hayashi, Koichiro ;

Nakamura, Michihiro ;

Miki, Hirokazu ;

Ozaki, Shuji ;

Abe, Masahiro ;

Matsumoto, Toshio ;

Ishimura, Kazunori .

ADVANCED FUNCTIONAL MATERIALS, 2012, 22 (17) :3539-3546

[6] A review of NIR dyes in cancer targeting and imaging [J].

Luo, Shenglin ;

Zhang, Erlong ;

Su, Yongping ;

Cheng, Tianmin ;

Shi, Chunmeng .

BIOMATERIALS, 2011, 32 (29) :7127-7138

[7] Molecular Rotors Based on the Boron Dipyrromethene Fluorophore [J].

Benniston, Andrew C. ;

Harriman, Anthony ;

Whittle, Victoria. L. ;

Zelzer, Mischa .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010, 2010 (03) :523-530

[8]

Investigation of the structures and absorption spectra for some hemicyanine dyes with pyridine nucleus by TD-DFT/PCM approach[J] . L.Y. Wang,Q.W. Chen,G.H. Zhai,Z.Y. Wen,Z.X. Zhang.Journal of Molecular Structure: THEOCHEM . 2006 (1)

[9]

Synthesis, properties, and photodynamic properties in vitro of heavy-chalcogen analogues of tetramethylrosamine[J] . Michael R Detty,Paras N Prasad,David J Donnelly,Tymish Ohulchanskyy,Scott L Gibson,Russell Hilf.Bioorganic & Medicinal Chemistry . 2004 (10)

[10] Rational design and synthesis of a novel class of highly fluorescent rhodamine dyes that have strong absorption at long wavelengths [J].

Liu, JX ;

Diwu, ZJ ;

Leung, WY ;

Lu, YX ;

Patch, B ;

Haugland, RP .

TETRAHEDRON LETTERS, 2003, 44 (23) :4355-4359

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