Crystal Structure and Interaction with DNA of [Ni(phen)(mal)(H2O)2]·3H2O

被引:0
作者
高恩君 [1 ]
程卯生 [2 ]
于影 [1 ]
孙亚光 [1 ]
机构
[1] Laboratory of Coordination Chemistry,Shenyang Institute of Chemical Technology  2. College of Pharmaceutical Engineering,Shenyang Pharmaceutical University
关键词
Ni(Ⅱ); molecular structure; weak interaction; DNA;
D O I
10.14102/j.cnki.0254-5861.2007.01.012
中图分类号
Q523 [脱氧核糖核酸(DNA)];
学科分类号
071010 ; 081704 ;
摘要
A new complex [Ni(phen)(mal)(H2O)2]·3H2O (phen = 1,10-phenanthroline, mal2-= malonic acid) has been synthesized by the reaction of nickel nitrate, phen and malonic acid. EA, IR spectra and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure of the title complex. Crystal data: monoclinic system, space group P2/c, a = 8.937(3), b = 12.163(5), c = 9.725(3) , β = 119.36°, C15H19N2O9Ni, Mr = 430.03, Z = 2, F(000) = 446, V = 921.3 3, Dc = 1.550 g/cm3, μ = 1.104 mm-1, –10≤h≤10, –12≤k≤14, –11≤l≤7, R = 0.0261 and wR = 0.0609 for 4376 (Rint = 0.0203) independent reflections and 1631 observed ones (I > 2σ(I)). Ni(Ⅱ) exhibits an octahedral coordination geometry, with hydrogen bonds and π-π interactions stabilizing the whole structure. UV spectrum of the complex interacting with protamine DNA indicates that the title compound interacts with DNA via insertion mode with bonding constant Kb of 1.11×104.
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页码:59 / 62
页数:4
相关论文
共 2 条
[1]  
Synthesis and structural characterization of a ( N , N ′-bis[2(S)-pyrrolidylmethyl]-propane-1,3-diamine) nickel (II) complex[J] . Amitabha Datta,Nirmal Kumar Karan,Samiran Mitra,Volker Gramlich.Journal of Chemical Crystallography . 2003 (7)
[2]  
Lemoine,P,Viossat,B,Morgant,G,Greenaway,F.T,Tomas,A,Dung,N.H,Sorenson,J.R.J. J.Inorg.Biochem . 2002