Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

被引：0

作者：

Li Qiang FuaXing Sheng GuobXin LiuaHui Li Hea Yu Ling WangbYu She Yanga a Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai China b School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang China ^{[1
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机构：

来源：

Chinese Chemical Letters | 2010年 / 21卷 / 05期

关键词：

Synthesis; Pleuromutilin; C-2(S)-substituted; Antimicrobial activity;

D O I：

暂无

中图分类号：

Q946 [植物生物化学];

学科分类号：

071001 ;

摘要：

<正>In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity.The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity,and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.

引用

页码：507 / 510

页数：4