Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis

被引：0
|
作者：
Dai Sik Ko [1 ]
Yun Hak Kim [2 ]
Tae Sik Goh [3 ]
Jung Sub Lee [3 ]
机构：
[1] Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center
[2] Department of Orthopaedic Surgery and Biomedical Research Institute, Pusan National University Hospital
[3] Department of Anatomy and Department of Biomedical Informatics, School of Medicine, Pusan National University
来源：
World Journal of Clinical Cases | 2020年 / 11期
基金：
新加坡国家研究基金会;
关键词：
Adolescent idiopathic scoliosis; Mesenchymal stem cell; Bioinformatics; Transcriptome; Proteome;
D O I：
暂无
中图分类号：
R726.8 [小儿骨科学];
学科分类号：
100202 ;
摘要：
Adolescent idiopathic scoliosis is the most common spinal deformity during puberty, especially in females. It is characterized by aberrant skeletal growth and generalized reduced bone density, which is associated with impaired bone mineral metabolism. Despite recent progress in multidisciplinary research to support various hypotheses, the pathogenesis of Adolescent idiopathic scoliosis is still not clearly understood. One of the hypothesis is to study the role of mesenchymal stem cells due to its involvement in the above-mentioned bone metabolic abnormalities. In this review, we will summarize reported literatures on the role of mesenchymal stem cells, particularly in the pathogenesis of Adolescent idiopathic scoliosis. In addition, we will describe the research on mesenchymal stem cells of Adolescent idiopathic scoliosis performed using bioinformatics tools.
引用
收藏
页码：2102 / 2110
页数：9
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