Long Non-coding RNAs in the Cytoplasm

被引：0

作者：

Farooq Rashid

Abdullah Shah

Ge Shan

机构：

[1] CASKeyLaboratoryofInnateImmunityandChronicDisease,CASCenterforExcellenceinMolecularCellScience,SchoolofLifeSciences,UniversityofScienceandTechnologyofChina

来源：

Genomics,Proteomics & Bioinformatics | 2016年 / 02期

关键词：

lncRNA; mRNA stability; mRNA translation; ceRNA; MicroRNA;

D O I：

暂无

中图分类号：

Q343 [细胞遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An enormous amount of long non-coding RNAs(lnc RNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability,regulating m RNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.

引用

页码：73 / 80

页数：8

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