Overview of the improvement of the ring-stage survival assay——a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum

被引:0
|
作者
Jie Zhang [1 ]
Guo-Hua Feng [2 ]
Chun-Yan Zou [3 ]
Pin-Can Su [4 ]
Huai-E Liu [1 ,5 ]
Zhao-Qing Yang [1 ]
机构
[1] Department of Pathogen Biology and Immunology, Kunming Medical University
[2] Biomedical Engineering Research Center, Kunming Medical University
[3] Guangxi Zhuang Autonomous Region People's Hospital
[4] Transfusion Medicine Research Department.Yunnan Kunming Blood Center
[5] Department of Infectious Diseases, The First Affiliated Hospital, Kunming Medical University
基金
中国国家自然科学基金;
关键词
Malaria; Artemisinin; Resistant phenotype; Ring-stage survival assay; Improvement; Application;
D O I
暂无
中图分类号
R531.3 [疟疾];
学科分类号
1002 ; 100201 ;
摘要
Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisininbased combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.
引用
收藏
页码:317 / 320
页数:4
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