The treatment of Parkinson's disease with deep brain stimulation: current issues

被引：7

作者：

Alexia-Sabine Moldovan ^{[1
]}

Stefan Jun Groiss ^{[1
]}

Saskia Elben ^{[1
]}

Martin Südmeyer ^{[1
]}

Alfons Schnitzler ^{[1
]}

Lars Wojtecki ^{[1
]}

机构：

[1] Center for Movement Disorders and Neuromodulation, Department of Neurology, University Hospital Düsseldorf, Germany & Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf

来源：

Neural Regeneration Research | 2015年 / 10卷 / 07期

关键词：

Parkinson’s disease; deep brain stimulation; subthalamic nucleus;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

Deep brain stimulation has become a well-established symptomatic treatment for Parkinson’s disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients’ mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation.

引用

页码：1018 / 1022

页数：5

共 29 条

[1]

Multiple source current steering – A novel deep brain stimulation concept for customized programming in a Parkinson’s disease patient[J] . Michael T. Barbe.Parkinsonism and Related Disorders . 2014 (4)

[2] Clinical Outcome of Subthalamic Stimulation in Parkinson's Disease is Improved by Intraoperative Multiple Trajectories Microelectrode Recording [J].

Reck, Christiane ;

Maarouf, Mohammad ;

Wojtecki, Lars ;

Groiss, Stefan Jun ;

Florin, Esther ;

Sturm, Volker ;

Fink, Gereon R. ;

Schnitzler, Alfons ;

Timmermann, Lars .

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY, 2012, 73 (06) :377-386

[3] Beta band stability over time correlates with Parkinsonian rigidity and bradykinesia [J].

Little, S. ;

Pogosyan, A. ;

Kuhn, A. A. ;

Brown, P. .

EXPERIMENTAL NEUROLOGY, 2012, 236 (02) :383-388

[4]

Randomized trial of deep brain stimulation for Parkinson disease: Thirty-six-month outcomes[J] . Frances M. Weaver,Kenneth A. Follett,Matthew Stern,Ping Luo,Crystal L. Harris,Kwan Hur,William J. Marks,Johannes Rothlind,Oren Sagher,Claudia Moy,Rajesh Pahwa,Kim Burchiel,Penelope Hogarth,Eugene C. Lai,John E. Duda,Kathryn Holloway,Ali Samii,Stacy Horn,Jeff M. Bronstein,Gatana Stoner,Philip A. Starr,Richard Simpson,Gordon Baltuch,Antonio De Salles,Grant D. Huang,Domenic J. Reda.Neurology . 2012 (1)

[5]

Subthalamic deep brain stimulation with a constant-current device in Parkinson’s disease: an open-label randomised controlled trial[J] . Lancet Neurology . 2012 (2)

[6] Effects of levodopa and deep brain stimulation on motor speech performance in Parkinson's disease [J].

Skodda, Sabine ;

Schlegel, Uwe ;

Sudmeyer, Martin ;

Schnitzler, Alfons ;

Wojtecki, Lars .

BASAL GANGLIA, 2012, 2 (01) :49-54

[7] Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism [J].

Rosin, Boris ;

Slovik, Maya ;

Mitelman, Rea ;

Rivlin-Etzion, Michal ;

Haber, Suzanne N. ;

Israel, Zvi ;

Vaadia, Eilon ;

Bergman, Hagai .

NEURON, 2011, 72 (02) :370-384

[8]

Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease （PD SURG trial）: a randomised, open-label trial[J] . Adrian Williams,Steven Gill,Thelekat Varma,Crispin Jenkinson,Niall Quinn,Rosalind Mitchell,Richard Scott,Natalie Ives,Caroline Rick,Jane Daniels,Smitaa Patel,Keith Wheatley.Lancet Neurology . 2010 (6)

[9] Current-controlled deep brain stimulation reduces in vivo voltage fluctuations observed during voltage-controlled stimulation [J].

Lempka, Scott F. ;

Johnson, Matthew D. ;

Miocinovic, Svjetlana ;

Vitek, Jerrold L. ;

McIntyre, Cameron C. .

CLINICAL NEUROPHYSIOLOGY, 2010, 121 (12) :2128-2133

[10]

Interleaving programming of subthalamic deep brain stimulation to reduce side effects with good motor outcome in a patient with Parkinson’s disease[J] . Lars Wojtecki.Parkinsonism and Related Disorders . 2010 (4)

← 1 2 3 →