Synthesis and preliminary biological evaluation of a technetium-99m labeled thymidine analog

被引：0

作者：

Chun Xiong LuabZheng Wu WangbcQuan Fu JiangaJie TangaCheng Tana Jian Kang Zhanga a Key Laboratory of Nuclear MedicineMinistry of HealthJiangsu Key Laboratory of Molecular Nuclear MedicineJiangsu Institute of Nuclear MedicineWuxi China b School of Chemical Material EngineeringJiangnan UniversityWuxi China c Department of Food Science TechnologySchool of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai China ^{[214063
,214122
,200240
]}

机构：

来源：

ChineseChemicalLetters | 2011年 / 22卷 / 11期

关键词：

Synthesis; 99mTc-NHT; Biodistribution; Thymidine analog; Tumor imaging;

D O I：

暂无

中图分类号：

O621.3 [有机合成化学];

学科分类号：

070303 ; 081704 ;

摘要：

<正>The synthesis and labeling of 99mTc-N3-（N'-[2-sulfanyl-ethylamino）acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine (99mTc-NHT) were studied.In the presence of sodium glucoheptonate（GH） and ethylene diamine tetraacetic acid（EDTA）,99mTc-NHT was obtained by using bisaminoethanethiol（N2S2） as a bifunctional coupling agent.The radiochemical purity of the 99mTc-NHT was over 95%.Biodistribution of 99mTc-NHT was performed in hepatoma HepA tumor-bearing mice.At 2 h p.i.,the ratios of tumor-to-muscle,tumor-to-bone and tumor-to-blood were 4.41±0.32,2.45±0.24 and 1.51±0.18,respectively.

引用

页码：1309 / 1312

页数：4

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