Effect of Helicobacter pylori infection on gastric epithelial apoptosis

被引：0

作者：

刘文忠

董全江

郑雄

萧树东

施尧

彭延申

机构：

[1] RenjiHospital,ShanghaiInstituteofDigestiveDisease,Shanghai

[2] DepartmentofInternalMedicine,WeifangMedicalCollege,ShandongProvince

来源：

中华内科杂志 | 1998年 / zk期

关键词：

Helicobacter; pylori; Apoptosis; Gastritis;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Objective To investigate the mechanism by which Helicobacter pylori induces gastric mucosal damage. Method The gastric epithelial apoptotic index (AI) of normal mucosa and H. pylori positive gastritis before and after anti-H. pylori treatment was studied using terminal transferase-mediated dUTP nick end labeling (TUNEL). Results The mean of AI was 7.1±1.6 in 31 patients with H. pylori positive gastritis and was significantly higher than 1.3±0.6 in 16 normal controls (P＜0.001). After the eradication of H. pylori AI fell significantly to the normal level (P＜0.001). In persisting H. pylori positive gastritis, the AI showed no significant change. There was no correlation between the AI and the severity of gastritis. Conclusion H. pylori infection could induce gastric epithelial apoptosis, which may be an important mechanism in the pathogenesis of gastric mucosal damage in H. pylori.

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