Studies on Structure-Activity Relationship of Nonquaternary AChE Reactivators

被引：0

作者：

焦克芳

宋鸿锵

卜志洁

机构：

[1] Institute of Pharmacology and Toxicology Beijing 100850 PRC

[2] Institute of Pharmacology and Toxicology Beijing 100850 PRC

来源：

Chinese Science Bulletin | 1993年 / 06期

基金：

中国国家自然科学基金;

关键词：

rate; AChE; Studies on Structure-Activity Relationship of Nonquaternary AChE Reactivators;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of dialkylaminoalkyl thioesters of α-keto thiohydroximic acid (4-RCH-COC·(NOH)-S-(CH)-NR′R″) as acetylcholinesterase (ACHE) reactivators in vitro were reported, whose correlations between oxime acid(α-keto thiohydromate acid) dissociation constants (pKa), Hammett values(σp) and rate of AChE reactivation were discussed by Bedford etal. They were considered as nonquaternary AChE reactivators based on the classical reactivative theory by the authors.

引用

页码：527 / 528

页数：2