Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

被引：0

作者：

Jiaxing Li ^{[1
,2
]}

Xiao Wang ^{[1
,2
]}

Jiayu Ding ^{[1
,2
]}

Yasheng Zhu ^{[1
,2
]}

Wenjian Min ^{[1
,2
]}

Wenbing Kuang ^{[1
,2
]}

Kai Yuan ^{[1
,2
]}

Chengliang Sun ^{[1
,2
]}

Peng Yang ^{[1
,2
]}

机构：

[1] State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University

[2] Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University

来源：

ActaPharmaceuticaSinicaB | 2022年 / 12卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R457.7 [骨髓移植];

学科分类号：

100215 ;

摘要：

Hematopoietic stem cell(HSC) transplantation is the only curative therapy for many diseases.HSCs from umbilical cord blood(UCB) source have many advantages over from bone marrow.However,limited HSC dose in a single CB unit restrict its widespread use.Over the past two decades,ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs.Till now,several small-molecule compounds have entered the phase Ⅰ/Ⅱ trials,showing safe and favorable pharmacological profiles.As HSC expansion has become a hot topic over recent years,many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue.Here,we will give an overview of HSC biology,discovery and medicinal chemistry development of small molecules,natural products targeting for HSC expansion,and their recent clinical progresses,as well as potential protein targets for HSC expansion.

引用

页码：2808 / 2831

页数：24

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