Relationship between the expression of matrix metalloproteinase-9 and angiogenesis in glioma and its clinical significance

被引：0

作者：

杨小立 ^{[1
]}

刘淼 ^{[1
]}

王茂德 ^{[2
]}

刘守勋 ^{[2
]}

王拓 ^{[2
]}

王鸿雁 ^{[3
]}

机构：

[1] Medical Center of Rehabilitation

[2] Department of Neurosurgery

[3] Department of Pathology,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University

来源：

Academic Journal of Xi'an Jiaotong University | 2008年 / 02期

关键词：

matrix metalloproteinase-9; glioma; angiogenesis; invasion;

D O I：

暂无

中图分类号：

R739.4 [神经系肿瘤];

学科分类号：

100214 ;

摘要：

Objective To explore the role and significance of matrix metalloproteinase-9(MMP-9)in angiogenesis through observing the relationship between the expression of MMP-9 and microvessel density(MVD)in glioma.Methods The expressions of MMP-9 and CD34 in 10 cases of normal brain tissues and 58 cases of glioma(14 cases of grade Ⅰ,20 cases of grade Ⅱ,15 cases of grade Ⅲ,and 9 cases of grade Ⅳ)were detected by immunohistochemical streptavidin-peroxidase technique.The positive cells of MMP-9 and the positive microvessels were examined under binocular light microscope.Results The positive expression of MMP-9 in glioma was located in the tumor-cell cytoplast and endothelial cells.The positive rate of MMP-9 in glioma of grade I,II,III and IV was 42.9%,65.0%,86.7% and 88.9%,respectively.The expression of MMP-9 was obviously higher than that of normal brain tissues(P<0.01)and positively correlated with glioma malignancy(rs=0.597,P<0.05).MVD was correlated with glioma malignancy(H=47.865,P<0.05).The expression of MMP-9 was significantly correlated with MVD(rs =0.897,P<0.01).Conclusion The expressions of MMP-9 and MVD are correlated with glioma malignancy,which may be helpful in judging the malignancy,invasion and prognosis.MMP-9 plays an important role in angiogenesis of glioma and accelerates glioma malignancy development by promoting angiogenesis.

引用

页码：113 / 118

页数：6

共 9 条

[1] 膀胱移行细胞癌组织中微血管密度与其生物学行为及预后的关系 [J].

郑凯 ;

张绍增 ;

王养民 ;

衡玲 .

中国临床康复, 2003, (26) :3586-3587+3669

[2] Pigment epithelium-derived factor inhibits glioma cell growth in vitro and in vivo [J].

Zhang, Tao ;

Guan, Ming ;

Xu, Chong ;

Chen, Yurning ;

Lu, Yuan .

LIFE SCIENCES, 2007, 81 (16) :1256-1263

[3] Antagonists of bombesin/gastrin-releasing peptide decrease the expression of angiogenic and anti-apoptotic factors in human glioblastoma [J].

Kanashiro, CA ;

Schally, AV ;

Cai, RZ ;

Halmos, G .

ANTI-CANCER DRUGS, 2005, 16 (02) :159-165

[4]

Mitsusuke Miyagami,Yoichi Katayama.Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel–Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein[J].Medical Molecular Morphology,2005(1)

[5] Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells [J].

Jadhav, U ;

Chigurupati, S ;

Lakka, SS ;

Mohanam, S .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2004, 25 (05) :1407-1414

[6]

Daizo Yoshida,Masahiro Noha,Kunihiro Watanabe,Yuichi Sugisaki,Akira Teramoto.SI-27, A Novel Inhibitor of Matrix Metalloproteinases with Antiangiogenic Activity: Detection with a Variable-pressure Scanning Electron Microscope[J].Neurosurgery,2002(3)

[7]

Miki Fujimura,Yvan Gasche,Yuiko Morita-Fujimura,Justin Massengale,Makoto Kawase,Pak H Chan.Early appearance of activated matrix metalloproteinase-9 and blood–brain barrier disruption in mice after focal cerebral ischemia and reperfusion[J].Brain Research,1999(1)

[8]

ZS Zeng,AM Cohen,JG Guillem.Cancer biology. Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis[J].Carcinogenesis,1999

[9]

Joon H. Uhm,Nora P. Dooley,Jean-Guy Villemure,Voon Wee Yong.Glioma invasion in vitro : regulation by matrix metalloprotease-2 and protein kinase C[J].Clinical & Experimental Metastasis,1996(5)

← 1 →