Antioxidant xanthones and anthraquinones isolated from a marine-derived fungus Aspergillus versicolor

被引:0
作者
WU ZeHong [1 ,2 ]
LIU Dong [2 ]
XU Ying [3 ]
CHEN JianLiang [1 ]
LIN WenHan [2 ]
机构
[1] The Eighth Affiliated Hospital, Sun Yat-sen University
[2] State Key Laboratory of Natural and Biomimetic Drugs, Peking University
[3] Shenzhen Key Laboratory of Marine Bioresource & Eco-environmental Science, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, College of Life Science, Shenzhen University
关键词
Aspergillus versicolor; Xanthones; Anthraquinones; Antioxidant activity; Cytotoxicity;
D O I
暂无
中图分类号
R915 [药物生物学];
学科分类号
1007 ;
摘要
Chemical examination of an EtO Ac extract of cultured Aspergillus versicolor fungus from deep-sea sediments resulted in the isolation of four xanthones, eight anthraquinones and five alkaloids, including a new xanthone, oxisterigmatocystin D(1) and a new alkaloid, aspergillusine A(13). High resolution electron impact mass spectrometry(HR-EI-MS), FT-IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configuration of compound 1 was established by its NMR features and coupling constant. Furthermore, the biosynthesis pathway of these xanthones and anthraquinones were deduced, and their antioxidant activity and cytotoxicity in human cancer cell lines(HTC-8, Bel-7420, BGC-823, A549, and A2780) were evaluated. The trolox equivalent antioxidant capacity(TEAC) assay indicated most of the xanthones and anthraquinones possessing moderate antioxidant activities. The Nrf2-dependent luciferase reporter gene assay revealed that compounds 6, 7, 9, and 12 potentially activated the expression of Nrf2-regulated gene. In addition, compounds 5 and 11 showed weak cytotoxicity on A549 with the IC50 values of 25.97 and 25.60 μmol×L–1, respectively.
引用
收藏
页码:219 / 224
页数:6
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