白细胞介素-17与类风湿关节炎

被引:12
|
作者
徐雪
吕玲
机构
[1] 复旦大学附属华山医院风湿科
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中图分类号
R593.22 [类风湿性关节炎];
学科分类号
摘要
<正>类风湿关节炎(rheumatoid arthritis,RA)是临床常见的一种自身免疫性疾病,致残率较高,严重影响患者的生活质量,其病因至今不明,但与免疫系统功能异常关系十分密切。其特征是:以慢性进行性关节病变为主,以非化脓性、增生性滑膜炎为特征,以局部关节反复发作为特点,逐渐导致关节软骨的破坏,最后以关节功能损失而致残。国内外大量的研究
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页码:719 / 721
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共 6 条
  • [1] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivanov, Ivaylo I.
    McKenzie, Brent S.
    Zhou, Liang
    Tadokoro, Carlos E.
    Lepelley, Alice
    Lafaille, Juan J.
    Cua, Daniel J.
    Littman, Dan R.
    [J]. CELL, 2006, 126 (06) : 1121 - 1133
  • [2] IL-17, IL-1β and TNF-α stimulate VEGF production by dedifferentiated chondrocytes[J] . Maria Cristina Honorati,Luca Cattini,Andrea Facchini.Osteoarthritis and Cartilage . 2004 (9)
  • [3] Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo
    Cai, LP
    Yin, JP
    Starovasnik, MA
    Hogue, DA
    Hillan, KJ
    Mort, JS
    Filvaroff, EH
    [J]. CYTOKINE, 2001, 16 (01) : 10 - 21
  • [4] Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage .2 Attur MG,Patel RN,Abramson SB,Amin AR. Arthritis Rheum . 1997
  • [5] Interleukin-17 enhances tumour necrosis factor alpha-induced synthesis of interleukins 1,6,and 8 in skin and synovial fibroblasts .2 Katz Y,Nadiv O,Beer Y. Arthritis Rheum . 2001
  • [6] IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes .2 Ryu,S,Lee,JH,Kim,SI. Clin Rheumatol . 2006