Transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides

被引：0

作者：

Meng-Xue Wei ^{[1
,2
]}

Xiao-Hui Gao ^{[2
]}

Tian-Cai Li ^{[2
]}

Chun-An Fan ^{[1
]}

Xue-Qiang Li ^{[2
]}

机构：

[1] State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University

[2] School of Chemistry and Chemical Engineering, Ningxia University

来源：

ChineseChemicalLetters | 2013年 / 24卷 / 09期

关键词：

Amination; Enamines; Butenolides; Tertiary amine; Transalkylation;

D O I：

暂无

中图分类号：

O621.25 [];

学科分类号：

摘要：

The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described.The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides;and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields.Interestingly,the product 2b has shown a promising anticancer activity against HeLa cell lines(IC50=0.19 mmol/L).

引用

页码：837 / 839

页数：3

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