The first catalytic asymmetric addition of diethylzinc to aldehyde promoted by chiral thiourea

被引：0
|
作者：
Zhi Guo Qiao
机构：
来源：
Chinese Chemical Letters | 2011年 / 22卷 / 11期
关键词：
Chiral thiourea; Diethylzinc; Amino alcohol; C2-symmetric; Enantioselective addition;
D O I：
暂无
中图分类号：
O621.25 [];
学科分类号：
摘要：
A series of C2-symmetric and asymmetric chiral thiourea derivatives were synthesized from commercial L-phenylalanine.All of the new compounds have been fully characterized by IR,~1H NMR,13C NMR,MS spectra and elemental analyses.The chiral thioureas were used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc,the corresponding sec-alcohols were gained with excellent enantioselectivities(up to 87.1%ee) and high yields(up to 76.7%) after the conditions were optimized.
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页码：1265 / 1268
页数：4
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