Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile

被引：0
|
作者：
Xiang Guo SHI
机构：
来源：
Chinese Chemical Letters | 2004年 / 04期
关键词：
Spiramycin; bitespiramycin; metabolites;
D O I：
暂无
中图分类号：
Q591 [物质代谢及能量代谢];
学科分类号：
摘要：
A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI-MSn). Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as Ml serial (spiramycin Ⅰ, Ⅱ, Ⅲ), M2 serial (platenomycin Al, josamycin and leucomycin Al) and M3 serial (deisovalerylplatenomycin Al, deisovaleryl-josamycin, deisovalerylleucomycin Al).
引用
收藏
页码：431 / 434
页数：4
相关论文
共 50 条
  • [21] EXCRETION OF PROBENECID AND ITS METABOLITES IN BILE AND URINE OF RATS
    CONWAY, WD
    MELETHIL, S
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1974, 63 (10) : 1551 - 1554
  • [22] CHARACTERIZATION OF METABOLITES OF ELLIPTICINE IN RAT BILE
    BRANFMAN, AR
    BRUNI, RJ
    REINHOLD, VN
    SILVEIRA, DM
    CHADWICK, M
    YESAIR, DW
    DRUG METABOLISM AND DISPOSITION, 1978, 6 (05) : 542 - 548
  • [23] CONJUGATED METABOLITES OF ESTRIOL IN RAT BILE
    NAMBARA, T
    KAWARADA, Y
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1975, 23 (03) : 698 - 700
  • [24] PHENOLIC METABOLITES OF MIDAZOLAM IN RAT BILE
    KOLIS, SJ
    WOO, GK
    WILLIAMS, TH
    SASSO, GJ
    SCHWARTZ, MA
    FEDERATION PROCEEDINGS, 1981, 40 (03) : 733 - 733
  • [25] EPOXIDE METABOLITES OF PROTRIPTYLINE IN RAT URINE
    HUCKER, HB
    BALLETTO, AJ
    DEMETRIADES, J
    ARISON, BH
    ZACCHEI, AG
    DRUG METABOLISM AND DISPOSITION, 1975, 3 (02) : 80 - 84
  • [26] IDENTIFICATION OF METABOLITES OF BROMACIL IN RAT URINE
    GARDINER, JA
    REISER, RW
    SHERMAN, H
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1969, 17 (05) : 967 - &
  • [27] IDENTIFICATION OF METABOLITES OF TERBACIL IN RAT URINE
    MAYO, BC
    POLLARD, AD
    HUCKSTEP, M
    BIGGS, SR
    HAWKINS, DR
    BRIGHTON CROP PROTECTION CONFERENCE : PESTS AND DISEASES - 1988, VOLS 1-3, 1988, : 681 - 686
  • [28] IDENTIFICATION OF FELODIPINE METABOLITES IN RAT URINE
    HOFFMANN, KJ
    WEIDOLF, L
    BIOMEDICAL MASS SPECTROMETRY, 1985, 12 (08): : 414 - 423
  • [29] New lignan metabolites in rat urine
    Smeds, AI
    Saarinen, NM
    Eklund, PC
    Sjholm, RE
    Mäkelä, SI
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 816 (1-2): : 87 - 97
  • [30] METABOLITES OF CLEMASTINE IN URINE AND FECES OF THE RAT
    GOBER, B
    ALMARDINI, MA
    FRANKE, P
    PHARMAZIE, 1989, 44 (12): : 847 - 851
12345