Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile

被引：0
|
作者：
Xiang Guo SHI
机构：
来源：
Chinese Chemical Letters | 2004年 / 04期
关键词：
Spiramycin; bitespiramycin; metabolites;
D O I：
暂无
中图分类号：
Q591 [物质代谢及能量代谢];
学科分类号：
摘要：
A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI-MSn). Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as Ml serial (spiramycin Ⅰ, Ⅱ, Ⅲ), M2 serial (platenomycin Al, josamycin and leucomycin Al) and M3 serial (deisovalerylplatenomycin Al, deisovaleryl-josamycin, deisovalerylleucomycin Al).
引用
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页码：431 / 434
页数：4
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