Pediatric lupus nephritis: Management update

被引：3

作者：

Rajiv Sinha ^{[1
]}

Sumantra Raut ^{[2
]}

机构：

[1] Division of Pediatric Nephrology,Department of Pediatrics, Institute of Child Health, Kolkata 700017,India

[2] Department of Pediatrics, Dr B C Roy Post Graduate Institute of Pediatric Sciences, Kolkata 700054, India

来源：

World Journal of Nephrology | 2014年 / 02期

关键词：

Pediatric; Lupus nephritis; Management; Monoclonal antibody; Cyclophosphamide; Mycophenolate mofetil;

D O I：

暂无

中图分类号：

R725.9 [小儿全身性疾病];

学科分类号：

100202 ;

摘要：

Childhood-onset systemic lupus erythematosus(c SLE) is a severe multisystem autoimmune disease. Renal involvement occurs in the majority of c SLE patients and is often fatal. Renal biopsy is an important investigation in the management of lupus nephritis. Treatment of renal lupus consists of an induction phase and maintenance phase. Treatment of childhood lupus nephritis using steroids is associated with poor outcome and excess side-effects. The addition of cyclophosphamide to the treatment schedule has improved disease control. In view of treatment failure using these drugs and a tendency for non-adherence, many newer agents such as immune-modulators and monoclonal antibodies are being tried in patients with c SLE. Trials of these novel agents in the pediatric population are still lacking making a consensus in the management protocol of pediatric lupus nephritis difficult.

引用

页码：16 / 23

页数：8

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