DIFFERENTIAL EXPRESSION OF GENES INVOLVED IN METABOLISM BETWEEN TUMORIGENITIC HUMAN LEUKEMIA CELL LINES K562 AND K562-n

被引：0

作者：

吕书晴

许小平

夏放

居小萍

李瑶

应康

毛裕民

机构：

[1] DepartmentofHematology,ChanghaiHospital,SecondMilitaryMedicalUniversity,DepartmentofHematology,ChanghaiHospital,SecondMilitaryMedicalUniversity,InstituteofGenetics,FudanUniversity,DepartmentofHematology,ChanghaiHospital,SecondMilitaryMedicalUniversity,Inst

来源：

Chinese Journal of Cancer Research | 2003年 / 02期

关键词：

Leukemic cell; Tumorigenicity; Geneexpression; Metabolism;

D O I：

暂无

中图分类号：

R733.7 [白血病];

学科分类号：

100214 ;

摘要：

Objective: To study the molecular mechanism ofdifferent tumorigenicity in nude mice of human leukemiacell lines K562-n and K562. Methods: To analyze the genes differently expressed between K562 and K562-n cells byusing cDNA microarray technique. Results: Among the12800 genes detected, some genes involved in materialmetabolism and material transport were differentlyexpressed between K562-n and K562 cells. These genesinclude homo sapiens placenta-specific ATP-binding cassette transporter gene, dihydrodiol dehydrogenase gene, hepatic dihydrodiol dehydrogenase gene, NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase,lysophosphatidic acid acyltransferase, alpha gene,argininosuccinate lyase gene, mitochondrial isocitrtatedehydrogenase, adhesion protein SQM1 gene, dimethylarginine dimethylamino-hydrolase gene, M1subunit of ribonucleotide reductase and farnesylpyrophosphate synthetase gene. Conclusion: The hightumorigenicity of K562-n cells is related to the differentexpression of some genes concerned with cell metabolismand material transpoert.

引用

页码：27 / 31

页数：5

共 18 条

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