Cu/chiral phosphoric acid-catalyzed radical-initiated asymmetric aminosilylation of alkene with hydrosilane

被引：0

作者：

Yang Zeng ^{[1
,2
]}

XiaoDong Liu ^{[1
,2
]}

XianQi Guo ^{[1
,2
]}

QiangShuai Gu ^{[3
,2
]}

ZhongLiang Li ^{[3
,2
]}

XiaoYong Chang ^{[2
]}

XinYuan Liu ^{[1
,2
]}

机构：

[1] Shenzhen Grubbs Institute, Southern University of Science and Technology

[2] Department of Chemistry, Southern University of Science and Technology

[3] Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology

来源：

Science China(Chemistry) | 2019年 / 11期

关键词：

asymmetric radical chemistry; aminosilylation; alkenes; Cu/chiral phosphoric acid; silyl radical;

D O I：

暂无

中图分类号：

O621.251 [];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu(I)/CPA cooperative catalysis has been developed. This method features the use of hydrosilane as the reductive radical precursor, enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine, indoline and isoindoline bearing an α-tertiary stereocenter with high enantioselectivity. The key to the success includes the use of Cu(I)/CPA cooperative catalyst system and the β-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.

引用

页码：1529 / 1536

页数：8